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Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Journal: Food Science & Nutrition

Article Title: Nobiletin Ameliorates Skeletal Muscle Performance in D‐Galactose‐Induced Aging Mice by Boosting Aerobic Metabolism

doi: 10.1002/fsn3.71416

Figure Lengend Snippet: Nob improved the antioxidant capacity of skeletal muscle in D‐gal‐induced aging mice. (A) ROS content, n = 3 mice/group; (B) SOD activity, n = 4 mice/group; (C) MDA content, n = 4 mice/group; (E–G) Western blot analysis of SIRT1, PGC‐1α, Nrf2, and GAPDH in D‐gal‐induced C2C12 cells treated with vehicle and Nob, n = 3. ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Article Snippet: SIRT‐1 inhibitor (EX‐527, HY‐15452) was obtained from MedChemExpress (Shanghai, China).

Techniques: Activity Assay, Western Blot